Fisetin has long been studied by longevity experts, because it can actively target senescent or aging cells. These are cells that were once healthy but no longer function optimally, a process known as cellular senescence. Over time, aging cells can accumulate and affect the day-to-day function of the healthy cells around them. A study published in the online journal BioMedicine found that, after testing 10 different flavonoids, fisetin proved to have the highest senolytic activity. This means it can encourage the body’s natural clearing and recycling process, supporting cellular health and longevity.
Fisetin also regulates sirtuin function, another critical aspect of cellular longevity. Sirtuin proteins are responsible for maintaining cells performing at their best, but sirtuin activity declines with age. Emerging research shows that fisetin encourages youthful, healthy sirtuin function. Fisetin also has antioxidant properties, which help support healthy brain function by inhibiting inflammatory factors and protecting delicate brain cells from oxidative stress.7 And by promoting healthy sugar metabolism and maintaining blood sugar levels within a normal range, fisetin protects eye and kidney health.
Fisetin has long been studied by longevity experts, because it can actively target senescent or aging cells. These are cells that were once healthy but no longer function optimally, a process known as cellular senescence. Over time, aging cells can accumulate and affect the day-to-day function of the healthy cells around them. A study published in the online journal BioMedicine found that, after testing 10 different flavonoids, fisetin proved to have the highest senolytic activity. This means it can encourage the body’s natural clearing and recycling process, supporting cellular health and longevity.
Fisetin also regulates sirtuin function, another critical aspect of cellular longevity. Sirtuin proteins are responsible for maintaining cells performing at their best, but sirtuin activity declines with age. Emerging research shows that fisetin encourages youthful, healthy sirtuin function. Fisetin also has antioxidant properties, which help support healthy brain function by inhibiting inflammatory factors and protecting delicate brain cells from oxidative stress.7 And by promoting healthy sugar metabolism and maintaining blood sugar levels within a normal range, fisetin protects eye and kidney health.