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Fisetin has long been studied by longevity experts, because it can actively target senescent or aging cells. These are cells that were once healthy but no longer function optimally, a process known as cellular senescence. Over time, aging cells can accumulate and affect the day-to-day function of the healthy cells around them. A study published in the online journal BioMedicine found that, after testing 10 different flavonoids, fisetin proved to have the highest senolytic activity. This means it can encourage the body’s natural clearing and recycling process, supporting cellular health and longevity.

Fisetin also regulates sirtuin function, another critical aspect of cellular longevity. Sirtuin proteins are responsible for maintaining cells performing at their best, but sirtuin activity declines with age. Emerging research shows that fisetin encourages youthful, healthy sirtuin function. Fisetin also has antioxidant properties, which help support healthy brain function by inhibiting inflammatory factors and protecting delicate brain cells from oxidative stress.7 And by promoting healthy sugar metabolism and maintaining blood sugar levels within a normal range, fisetin protects eye and kidney health.

Fisetin has loads of health benefits. But much of the Fisetin you ingest turns into inactive metabolites through the digestive process. So Life Extension's created a formula that helps preserve Fisetin, so you get the maximum benefit. Read more about Fisterin from the NIH here.

Take one (1) capsule daily, or as recommended by a healthcare practitioner. 

Serving Size: 1 Vegetarian Capsule

Amount Per Serving

Proprietary Blend … 44.5mg**

Providing 18% fisetin  … 8mg

[from wax tree extract (stem)]

35% Galactomannans … 15 mg

[from fenugreek (seed)]

Other Ingredients: Microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate, soluble fiber, sunflower lecithin.

This product is Non-GMO, Gluten Free. 



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undergoing treatment for a medical condition

or if you are pregnant or lactating.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease

Disclaimer:The Pretty Hot Mess will not be held responsible for any claims or testimonials regarding medical efficacy of any of our products. The FDA (Food and Drug Administration) has not evaluated any of these statements, nor have the claims been confirmed by FDA-acknowledged research. Neither our staff nor our products are intended to diagnose, cure, prevent, or treat any disease or medical condition. Please consult your physician before including any of our products in your wellness plan.

This product has not been evaluated by the FDA. It is not intended to treat, cure, diagnose or prevent any disease.

Caution: Do not use if pregnant or nursing or if you have any diagnosed or undiagnosed health conditions. Do not use these products while taking any prescription or non-prescription drugs without consulting with your health care provider. Keep away from children. 

The Manufacturer and The Pretty Hot Mess, LLC cannot be held responsible, nor assume responsibility for any individual who consumes or misuses this product.This product should be used only as directed on the label or by your health care provider. This product is not intended to diagnose, treat, cure or prevent any disease. 

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